Antimalarial Drugs Artesunate, Artemether and Artemisin-Based Combination Therapies (ACTS) Have Promising Anti-Sars-Cov-2 (Covid-19) Effects. A Mini Review

Vol – 2 | Issue – 1 | Jan – 2024

Abstract:  There is accumulating emerging evidences on the extended therapeutic potential of antimalarial drugs, particularly artemisinin derivatives have anti-SARS-CoV-2(COVID-19) effects. The artemisinin derivative Artesunate and Artemether have most promising agents exhibiting improved pharmacokinetic properties and have pleotropic effects. Artemisinin-based combination therapy (ACT) at recommended doses clinically used in malaria, showed in-vitro inhibition of SARS-CoV-2 replication and ACTs containing Artemether/Artesunate in combination with Lumefantrine/Mefloquine/Amodiaquine would be attractive candidates for treatment of COVID-19 considering their excellent safety profiles in humans and  available at a relatively low cost.

Keywords: SARS-CoV-2, COVID-19, ACT, Artesunate, Artemether, Lumefantrine, Amodiaquine.

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