Study Analytical and Spectrophotometric Methods for Estimation of Ferrous (II) Ion in Pharmaceutical Formulation Using a Paracetamol (PCT) Azo Reagent

A simple, fast, and the sensitive spectrophotometric method for measuring trace amounts of iron (II) was developed based on the complex formation between ferrous (II) and the paracetamol (PCT) azo reagent in an acidic medium. The paracetamol (PCT) azo reagent has been developed for ferrous ion analysis. The calibration curves were linear throughout the ferrous (II) concentration range of 1–8 g/ml–1µg/ml. The effects of foreign ions and species on the measurement of Fe (II) was investigated in order to assess the methods’ selectivity. Both the production of pharmaceuticals and the detection of pure ferrous metals were successfully accomplished using the recommended methods. There was strong agreement between the results of the reference technique and the recommended approaches.