2024
- Balasubramanian Karpagam*1, Jegathalaprathapan Rajesh2 and Gurusamy Rajagopal3
- 1*Department of Chemistry, St. Michael College of Engineering and Technology, Kalayarkoil, Sivaganga District, Tamilnadu 630551, India. 2Department of Chemistry, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu 602105, India. 3PG & Research Department of Chemistry, Chikkanna Government Arts College, Tiruppur-641 602, India
- GAS Journal of Clinical Medicine and Medical Research (GASJCMMR)
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Abstract:
A new class of
metal complexes of type M(X)2 [where M = Cu(II)
X=1-(3-ethoxy-2-hydroxybenzilidene-4-phenylsemicarbazide) have been
characterized by spectral techniques. In the visible range, the complexes
exhibit a strong Metal to Ligand Charge transfer (MLCT) transition. The
bonding through imine nitrogen and deprotonate phenolic oxygen is
demonstrated by the ligands’ reduced frequency shift (ν(C=N)) and absence of
v(O–H) in the IR spectral measurements upon complexation with the metal atom.
In their complexes, the Schiff bases exhibit the properties of monobasic
tridentate ligands. The spectrum data show that the nitrogen atoms in
azomethine and the phenolic oxygen serve as the ligand’s points of
coordination. The observed A|| values in the Cu (II) complexes indicate a
tetrahedrally distorted square planar structure. The metal complexes are
screened for biopotency. The Ligand (L1)
and their complexes of Cu (II) show
cytotoxicity in human adrenocarcinoma breast cancer cells giving IC50
values for Cu (II) complexes 55.52, 58.96 μg, respectively. The
results demonstrate that Cu (II) complexes, with potent antiproliferative
activity, is able to induce caspase-dependent apoptosis in human cancer
cells. Cytotoxicity of the complexes is further confirmed by the MCF-7 cancer
cells. |
Keywords:
Schiff base, Cu (II) Complex, biopotency, apoptosis
