- Balasubramanian Karpagam*1, Jegathalaprathapan Rajesh2 and Gurusamy Rajagopal3
- 1*Department of Chemistry, St. Michael College of Engineering and Technology, Kalayarkoil, Sivaganga District, Tamilnadu 630551, India. 2Department of Chemistry, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu 602105, India. 3PG & Research Department of Chemistry, Chikkanna Government Arts College, Tiruppur-641 602, India
A new class of metal complexes of type M(X)2 [where M
= Cu(II) X=1-(3-ethoxy-2-hydroxybenzilidene-4-phenylsemicarbazide) have been
characterized by spectral techniques. In the visible range, the complexes
exhibit a strong Metal to Ligand Charge transfer (MLCT) transition. The bonding
through imine nitrogen and deprotonate phenolic oxygen is demonstrated by the
ligands’ reduced frequency shift (ν(C=N)) and absence of v(O–H) in the IR
spectral measurements upon complexation with the metal atom. In their
complexes, the Schiff bases exhibit the properties of monobasic tridentate
ligands. The spectrum data show that the nitrogen atoms in azomethine and the
phenolic oxygen serve as the ligand’s points of coordination.
The observed A|| values in the Cu (II) complexes indicate a tetrahedrally distorted square planar structure. The metal complexes are screened for biopotency. The Ligand (L1) and their complexes of Cu (II) show cytotoxicity in human adrenocarcinoma breast cancer cells giving IC50 values for Cu (II) complexes 55.52, 58.96 μg, respectively. The results demonstrate that Cu (II) complexes, with potent antiproliferative activity, is able to induce caspase-dependent apoptosis in human cancer cells. Cytotoxicity of the complexes is further confirmed by the MCF-7 cancer cells.
